Mojo Jojo is tired of being put down by the Powerpuff girls and now he has come with a grandiose scheme to defeat them...Radio Jojo! But he doesn't know that his signals have summoned aliens who are hell bent upon destroying Townsville. You take on the character of Bubbles, Blossom or Buttercup and battle your way through numerous levels full of innovative missions and fantastic clashes in a 3D Townsville world. Defeat Mojo and the aliens or the Powerpuff girls die in POWERPUFF GIRLS RELISH RAMPAGE.